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Meet our new postdoc - Nace Mikus

New face at IMC

Photo of Nace Mikus
Nace Mikus

Nace Mikus is a Postdoctoral Research Fellow at the Interacting Minds Centre (IMC), contributing to the Wellcome Trust-funded project, "Certain About Uncertainty: Bridging Cells and the Clinic to Uncover Causal Mechanisms of Anxiety Interventions." His work encompasses a broad spectrum of research areas including clinical psychopharmacology, computational psychiatry, and preclinical studies in rodents. His PhD thesis focused on elucidating the effects of antipsychotic drugs on computational mechanisms underlying aberrant belief updating in schizophrenia patients.

Currently, Nace is dedicated to exploring the relationship between intolerance of uncertainty and anxiety, and how uncertainty processing is affected by targeted psychological therapies and anti-anxiety medications that affect serotonin and noradrenaline levels. In the Certain About Uncertainty Project the aim is to establish a computational framework, supported by experimental paradigms, to identify an individual's 'uncertainty fingerprint.' This concept refers to a unique measure of how individuals process various forms of uncertainty across different contexts. By integrating research across different scales and species, the project intends to uncover the mechanisms through which anxiety medications and psychological therapies ameliorate symptoms by altering the brain's encoding of uncertainty.